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KMID : 0043320120350050801
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Archives of Pharmacal Research
2012 Volume.35 No. 5 p.801 ~ p.805
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Bioassay-guided isolation of novel compound from Paeonia suffruticosa Andrews roots as an IL-1β inhibitor
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Choi Yun-Hyeok
Yoo Hee-Jung
Noh Ill-Chan
Lee Jeong-Min
Park Jae-Won
Choi Wahn-Soo
Choi Jung-Ho
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Abstract
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The inhibition of Interleukin-1beta (IL-1β) is of substantial interest for the treatment of rheumatoid arthritis. Using an in vitro assay with RAW 264.7 cells, oxo-acetic acid 2-ethoxy-4-(3-hydroxy-2-oxopropyl) phenyl ester (1) was isolated from the roots of Paeonia suffruticosa Andrews as an inhibitor of IL-1β with an IC50 value of 56 μM. Compound 1 is a novel phenylesteric compound from P. suffruticosa Andrews. Compound 1 was shown to inhibit the production of pro-inflammatory cytokines in RAW 264.7 cells. Thus, a possible new action of novel compound is provided explaining the anti-rheumatoid arthritic properties of P. suffruticosa Andrews.
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KEYWORD
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IL-1β inhibitor, Anti-inflammatory, Paeonia suffruticosa Andrews, Oxo-acetic acid 2-ethoxy-4-(3-hydroxy-2-oxopropyl) phenyl ester, Lipopolysaccharide (LPS), RAW 264.7 cell
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